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Inflammatory bowel disease

MedGen UID:
43877
•Concept ID:
C0021390
•
Disease or Syndrome
Synonyms: Bowel Diseases, Inflammatory; Inflammatory Bowel Disease; Inflammatory Bowel Diseases
SNOMED CT: Inflammatory bowel disease (24526004); IBD - inflammatory bowel disease (24526004)
 
Monarch Initiative: MONDO:0005265
OMIM® Phenotypic series: PS266600
Orphanet: ORPHA104012

Definition

Inflammatory bowel disease is a systemic disorder comprised of two major disorders: ulcerative colitis and Crohn disease. Crohn disease can affect any part of the digestive system while ulcerative colitis is confined to the colon. Both disorders may affect sites outside of the digestive system [from SNOMEDCT_US]

Professional guidelines

PubMed

ACG Clinical Guideline: Management of Irritable Bowel Syndrome.
Lacy BE, Pimentel M, Brenner DM, Chey WD, Keefer LA, Long MD, Moshiree B
Am J Gastroenterol 2021 Jan 1;116(1):17-44. doi: 10.14309/ajg.0000000000001036. PMID: 33315591
British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.
Lamb CA, Kennedy NA, Raine T, Hendy PA, Smith PJ, Limdi JK, Hayee B, Lomer MCE, Parkes GC, Selinger C, Barrett KJ, Davies RJ, Bennett C, Gittens S, Dunlop MG, Faiz O, Fraser A, Garrick V, Johnston PD, Parkes M, Sanderson J, Terry H; IBD guidelines eDelphi consensus group, Gaya DR, Iqbal TH, Taylor SA, Smith M, Brookes M, Hansen R, Hawthorne AB
Gut 2019 Dec;68(Suppl 3):s1-s106. Epub 2019 Sep 27 doi: 10.1136/gutjnl-2019-318484. PMID: 31562236Free PMC Article
A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease.
Seyedian SS, Nokhostin F, Malamir MD
J Med Life 2019 Apr-Jun;12(2):113-122. doi: 10.25122/jml-2018-0075. PMID: 31406511Free PMC Article

Curated

UK NICE Clinical Guideline CG118, Colorectal cancer prevention: colonoscopic surveillance in adults with ulcerative colitis, Crohn's disease or adenomas, 2022

Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression risk

Recent clinical studies

Etiology

Dietary Interventions in Inflammatory Bowel Disease.
Godala M, Gaszyńska E, Zatorski H, Małecka-Wojciesko E
Nutrients 2022 Oct 12;14(20) doi: 10.3390/nu14204261. PMID: 36296945Free PMC Article
Environmental risk factors for inflammatory bowel disease.
Singh N, Bernstein CN
United European Gastroenterol J 2022 Dec;10(10):1047-1053. Epub 2022 Oct 19 doi: 10.1002/ueg2.12319. PMID: 36262056Free PMC Article
Implications of the changing epidemiology of inflammatory bowel disease in a changing world.
Agrawal M, Jess T
United European Gastroenterol J 2022 Dec;10(10):1113-1120. Epub 2022 Oct 17 doi: 10.1002/ueg2.12317. PMID: 36251359Free PMC Article
The Gut Microbiota in Inflammatory Bowel Disease.
Qiu P, Ishimoto T, Fu L, Zhang J, Zhang Z, Liu Y
Front Cell Infect Microbiol 2022;12:733992. Epub 2022 Feb 22 doi: 10.3389/fcimb.2022.733992. PMID: 35273921Free PMC Article
Mendelian randomization study of inflammatory bowel disease and bone mineral density.
Wu F, Huang Y, Hu J, Shao Z
BMC Med 2020 Nov 10;18(1):312. doi: 10.1186/s12916-020-01778-5. PMID: 33167994Free PMC Article

Diagnosis

Inflammatory Bowel Disease.
Bruner LP, White AM, Proksell S
Prim Care 2023 Sep;50(3):411-427. Epub 2023 May 10 doi: 10.1016/j.pop.2023.03.009. PMID: 37516511
Inflammatory bowel disease biomarkers.
Liu D, Saikam V, Skrada KA, Merlin D, Iyer SS
Med Res Rev 2022 Sep;42(5):1856-1887. Epub 2022 May 23 doi: 10.1002/med.21893. PMID: 35603998Free PMC Article
Mendelian randomization study of inflammatory bowel disease and bone mineral density.
Wu F, Huang Y, Hu J, Shao Z
BMC Med 2020 Nov 10;18(1):312. doi: 10.1186/s12916-020-01778-5. PMID: 33167994Free PMC Article
Exosome-mediated effects and applications in inflammatory bowel disease.
Ocansey DKW, Zhang L, Wang Y, Yan Y, Qian H, Zhang X, Xu W, Mao F
Biol Rev Camb Philos Soc 2020 Oct;95(5):1287-1307. Epub 2020 May 14 doi: 10.1111/brv.12608. PMID: 32410383Free PMC Article
Early-Onset Inflammatory Bowel Disease.
Kelsen JR, Russo P, Sullivan KE
Immunol Allergy Clin North Am 2019 Feb;39(1):63-79. doi: 10.1016/j.iac.2018.08.008. PMID: 30466773Free PMC Article

Therapy

Navigating the complexities of drug development for inflammatory bowel disease.
Honap S, Jairath V, Danese S, Peyrin-Biroulet L
Nat Rev Drug Discov 2024 Jul;23(7):546-562. Epub 2024 May 22 doi: 10.1038/s41573-024-00953-0. PMID: 38778181
Ozanimod: A Review in Ulcerative Colitis.
Paik J
Drugs 2022 Aug;82(12):1303-1313. Epub 2022 Aug 22 doi: 10.1007/s40265-022-01762-8. PMID: 35994200Free PMC Article
Colostrum Therapy for Human Gastrointestinal Health and Disease.
Chandwe K, Kelly P
Nutrients 2021 Jun 7;13(6) doi: 10.3390/nu13061956. PMID: 34200282Free PMC Article
The Role of Early Biologic Therapy in Inflammatory Bowel Disease.
Berg DR, Colombel JF, Ungaro R
Inflamm Bowel Dis 2019 Nov 14;25(12):1896-1905. doi: 10.1093/ibd/izz059. PMID: 30934053Free PMC Article
Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease.
Weingarden AR, Vaughn BP
Gut Microbes 2017 May 4;8(3):238-252. Epub 2017 Feb 10 doi: 10.1080/19490976.2017.1290757. PMID: 28609251Free PMC Article

Prognosis

Implications of the changing epidemiology of inflammatory bowel disease in a changing world.
Agrawal M, Jess T
United European Gastroenterol J 2022 Dec;10(10):1113-1120. Epub 2022 Oct 17 doi: 10.1002/ueg2.12317. PMID: 36251359Free PMC Article
The Burden of Inflammatory Bowel Disease in Europe in 2020.
Zhao M, Gönczi L, Lakatos PL, Burisch J
J Crohns Colitis 2021 Sep 25;15(9):1573-1587. doi: 10.1093/ecco-jcc/jjab029. PMID: 33582812
Incidence and Prevalence of Inflammatory Bowel Disease across Asia.
Park J, Cheon JH
Yonsei Med J 2021 Feb;62(2):99-108. doi: 10.3349/ymj.2021.62.2.99. PMID: 33527789Free PMC Article
The four epidemiological stages in the global evolution of inflammatory bowel disease.
Kaplan GG, Windsor JW
Nat Rev Gastroenterol Hepatol 2021 Jan;18(1):56-66. Epub 2020 Oct 8 doi: 10.1038/s41575-020-00360-x. PMID: 33033392Free PMC Article
Evolving Epidemiology of IBD.
Windsor JW, Kaplan GG
Curr Gastroenterol Rep 2019 Jul 23;21(8):40. doi: 10.1007/s11894-019-0705-6. PMID: 31338613

Clinical prediction guides

Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.
Rogler G, Singh A, Kavanaugh A, Rubin DT
Gastroenterology 2021 Oct;161(4):1118-1132. Epub 2021 Aug 3 doi: 10.1053/j.gastro.2021.07.042. PMID: 34358489Free PMC Article
Calprotectin: from biomarker to biological function.
Jukic A, Bakiri L, Wagner EF, Tilg H, Adolph TE
Gut 2021 Oct;70(10):1978-1988. Epub 2021 Jun 18 doi: 10.1136/gutjnl-2021-324855. PMID: 34145045Free PMC Article
American Gastroenterological Association Institute Guideline on Therapeutic Drug Monitoring in Inflammatory Bowel Disease.
Feuerstein JD, Nguyen GC, Kupfer SS, Falck-Ytter Y, Singh S; American Gastroenterological Association Institute Clinical Guidelines Committee
Gastroenterology 2017 Sep;153(3):827-834. Epub 2017 Aug 3 doi: 10.1053/j.gastro.2017.07.032. PMID: 28780013
Gastrointestinal Behçet's disease: a review.
Skef W, Hamilton MJ, Arayssi T
World J Gastroenterol 2015 Apr 7;21(13):3801-12. doi: 10.3748/wjg.v21.i13.3801. PMID: 25852265Free PMC Article
The diagnostic approach to monogenic very early onset inflammatory bowel disease.
Uhlig HH, Schwerd T, Koletzko S, Shah N, Kammermeier J, Elkadri A, Ouahed J, Wilson DC, Travis SP, Turner D, Klein C, Snapper SB, Muise AM; COLORS in IBD Study Group and NEOPICS
Gastroenterology 2014 Nov;147(5):990-1007.e3. Epub 2014 Jul 21 doi: 10.1053/j.gastro.2014.07.023. PMID: 25058236Free PMC Article

Recent systematic reviews

High-Fiber Diet and Crohn's Disease: Systematic Review and Meta-Analysis.
Serrano Fernandez V, Seldas Palomino M, Laredo-Aguilera JA, Pozuelo-Carrascosa DP, Carmona-Torres JM
Nutrients 2023 Jul 12;15(14) doi: 10.3390/nu15143114. PMID: 37513532Free PMC Article
Dietary Interventions for the Treatment of Inflammatory Bowel Diseases: An Updated Systematic Review and Meta-analysis.
Limketkai BN, Godoy-Brewer G, Parian AM, Noorian S, Krishna M, Shah ND, White J, Mullin GE
Clin Gastroenterol Hepatol 2023 Sep;21(10):2508-2525.e10. Epub 2022 Dec 5 doi: 10.1016/j.cgh.2022.11.026. PMID: 36470529
A Systematic Review of Monogenic Inflammatory Bowel Disease.
Nambu R, Warner N, Mulder DJ, Kotlarz D, McGovern DPB, Cho J, Klein C, Snapper SB, Griffiths AM, Iwama I, Muise AM
Clin Gastroenterol Hepatol 2022 Apr;20(4):e653-e663. Epub 2021 Mar 18 doi: 10.1016/j.cgh.2021.03.021. PMID: 33746097Free PMC Article
Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.
Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R, Ghosh S, Wu JCY, Chan FKL, Sung JJY, Kaplan GG
Lancet 2017 Dec 23;390(10114):2769-2778. Epub 2017 Oct 16 doi: 10.1016/S0140-6736(17)32448-0. PMID: 29050646
Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target.
Peyrin-Biroulet L, Sandborn W, Sands BE, Reinisch W, Bemelman W, Bryant RV, D'Haens G, Dotan I, Dubinsky M, Feagan B, Fiorino G, Gearry R, Krishnareddy S, Lakatos PL, Loftus EV Jr, Marteau P, Munkholm P, Murdoch TB, Ordás I, Panaccione R, Riddell RH, Ruel J, Rubin DT, Samaan M, Siegel CA, Silverberg MS, Stoker J, Schreiber S, Travis S, Van Assche G, Danese S, Panes J, Bouguen G, O'Donnell S, Pariente B, Winer S, Hanauer S, Colombel JF
Am J Gastroenterol 2015 Sep;110(9):1324-38. Epub 2015 Aug 25 doi: 10.1038/ajg.2015.233. PMID: 26303131

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    Clinical resources

    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Clinical Guideline CG118, Colorectal cancer prevention: colonoscopic surveillance in adults with ulcerative colitis, Crohn's disease or adenomas, 2022
    • Nguyen et al., 2011
      Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression risk

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    Reviews

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